I was recently trying to re-provision a solution through Farm Solutions within Central Administration Service for Sharepoint.
Once I clicked deploy on the solution I got the below error:
Access denied. Only machine administrators are allow to create administration……

Weird. I doubled check that I had the correct permissions, which I did.
Solution:
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Run Internet Explorer as Administrator by holding shift key and right clicking on the Internet Explorer icon and select Run as Administrator.
This will then run IE under the machine Administrator account.